中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (29): 4723-4728.doi: 10.12307/2022.903

• 组织构建综述 tissue construction review • 上一篇    下一篇

基于Citespace软骨前体细胞修复软骨相关文献的可视化分析

何其泽1,孟  林2,王  杰1,翁晨祎1   

  1. 1广西中医药大学瑞康临床医学院,广西壮族自治区南宁市  530000;2广西骨伤医院关节科,广西壮族自治区南宁市  530012
  • 收稿日期:2021-10-11 接受日期:2021-11-09 出版日期:2022-10-18 发布日期:2022-03-28
  • 通讯作者: 孟林,博士,副主任医师,广西骨伤医院,广西壮族自治区南宁市 530012
  • 作者简介:何其泽,男,1994年生,广东省高州市人,汉族,广西中医药大学在读硕士,主要从事骨关节相关疾病的中西医结合治疗研究。
  • 基金资助:
    全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号),项目负责人:孟林;广西骨伤医院重点课题(GXGSZD_2019003),项目负责人:孟林,项目名称:基于Runx2蛋白双向表达探讨壮药虾须草对大鼠激素型股骨头坏死的预防作用

Citespace-based visual analysis of research literature related to cartilage repair using cartilage precursor cells

He Qize1, Meng Lin2, Wang Jie1, Weng Chenyi1   

  1. 1Ruikang Clinical College, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China; 2Department of Arthritis, Guangxi Orthopedics Hospital, Nanning 530012, Guangxi Zhuang Autonomous Region, China
  • Received:2021-10-11 Accepted:2021-11-09 Online:2022-10-18 Published:2022-03-28
  • Contact: Meng Lin, MD, Associate chief physician, Department of Arthritis, Guangxi Orthopedics Hospital, Nanning 530012, Guangxi Zhuang Autonomous Region, China
  • About author:He Qize, Master candidate, Ruikang Clinical College, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    the National TCM Innovative Talents Training Project, No. [2019]128 (to ML); the Key Project of Guangxi Orthopedics Hospital, No. GXGSZD_2019003 (to ML)

摘要:

文题释义:
软骨前体细胞:来源于关节软骨中具有自我增殖性、干细胞表面抗原表达特性及多向分化潜能的软骨细胞亚群,在一定条件下可向相应组织的成熟细胞分化,软骨前体细胞也称为软骨祖细胞、软骨前体干细胞,在软骨退变和再生中发挥重要作用。
软骨细胞外泌体:外泌体是由细胞分泌的囊泡结构,其结构特点是由脂质双分子层包裹着多种mRNA、miRNA以及蛋白质等小分子。外泌体是细胞与细胞之间进行交流的重要媒介,通过各种信号转导通路,能够发挥类似软骨干细胞更为优异的对病变的修复作用。软骨细胞外泌体指的是来源于软骨细胞的外泌体。

背景:软骨修复一直是骨科医生面临的巨大挑战,同时也一直是研究的热点,近年来研究发现关节软骨中存在一类具有干细胞特征的软骨前体细胞,为软骨损伤修复研究提供了新的切入点。
目的:通过对软骨前体细胞的相关文献进行发文趋势分析、作者合作网络分析、机构合作网络分析,对关键词进行共现分析、聚类分析,探索该领域近20年的发展状况、研究热点及难点,为软骨修复相关的科研以及临床工作提供新的思路和方向。
方法:以Web of Science中1999-2021收录的核心合集数据库为文献来源,应用Citespace 5.8.R1进行文献可视化分析,并绘制相关可视化图谱。
结果与结论:①共纳入文献829篇,分析结果显示:该领域每年的发文量基本稳定在30-50篇,略有下降趋势,发文量最多的作者为CHUANJU LIU,机构为Harvard Univ,高频关键词有20个,形成12个有意义的聚类。②间充质干细胞、软骨细胞、破骨细胞、骨髓基质细胞、基质细胞等是当前研究热点;软骨前体细胞目前的研究关注度不高,未来仍有巨大的发掘空间,目前大部分研究都是基于应用组织工程材料结合细胞对软骨缺损修复。③关注软骨细胞以及软骨前体细胞来源、外泌体的应用、组织-支架相互作用和支架降解、识别和运用新的刺激、理解结构的成熟、生物力学和功能、改进植入、固定和康复方法仍然是软骨修复研究的前沿热点。

https://orcid.org/0000-0001-8917-7221(何其泽);https://orcid.org/0000-0003-2977-9508(孟林) 

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 软骨, 修复, 关节, 干细胞, 软骨前体细胞, Citespace软件, 文献计量学, 可视化分析

Abstract: BACKGROUND: Cartilage repair has always been a great challenge for orthopedic surgeons and also a hot issue in relevant fields. Recent studies have revealed the existence of cartilage progenitor cells with stem cell characteristics in the articular cartilage, providing a new entry point for cartilage repair.
OBJECTIVE: By analyzing the trend of publications, author collaboration network, institutional collaboration network, co-occurrence analysis and clustering analysis of keywords in the cartilage progenitor cells-related literature, to explore the development status, research hotspots and difficulties in this field in the past 20 years, and to provide new ideas and directions for cartilage repair-related scientific research as well as clinical work.
METHODS: The core ensemble database included in Web of Science 1999-2021 was used as the literature source, and Citespace 5.8.R1 was applied to visualize and analyze relevant literature and draw relevant visualization maps.
RESULTS AND CONCLUSION: A total of 829 papers were included, and the analysis results showed that: the annual publication volume was basically stable at 30-50 articles with a slight downward trend; CHUANJU LIU had the most publications and the institution with the most publications was Harvard Univ; and there were 20 high-frequency keywords that formed 12 meaningful clusters. Mesenchymal stem cells, chondrocytes, osteoblasts, bone marrow stromal cells, and stromal cells are the current research hotspots. Cartilage precursor cells are currently of little research concern, and there is still great room for future exploration. Most of the current research on cartilage precursor cells focuses on the application of tissue engineering materials combined with the cells for cartilage defect repair. Current frontier hotspots in cartilage repair research include the sources of chondrocytes and cartilage precursor cells, application of exosomes, tissue-scaffold interactions and scaffold degradation, identification and application of new stimuli, understanding structural maturation, biomechanics and function, and improving implantation, fixation and rehabilitation methods.

Key words: cartilage, repair, joint, stem cell, cartilage precursor cell, Citespace software, bibliometrics, visual analysis

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