中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (26): 4252-4257.doi: 10.12307/2022.831

• 组织构建综述 tissue construction review • 上一篇    下一篇

香芹酚抗感染、修复骨损伤及防治口腔疾病的作用

张子晗,王文丽,李金诺,李友瑞   

  1. 滨州医学院附属医院,山东省滨州市  256600
  • 收稿日期:2021-09-18 接受日期:2021-10-25 出版日期:2022-09-18 发布日期:2022-03-09
  • 通讯作者: 李友瑞,医学博士,副主任医师,滨州医学院附属医院口腔修复科,山东省滨州市 256600
  • 作者简介:张子晗,女,1995年生,天津市人,滨州医学院附属医院在读硕士,主要从事种植修复研究。
  • 基金资助:
    山东省医药卫生科技发展项目(2017WS753),项目负责人:李友瑞;滨州医学院科技计划项目(BY2016KJ006),项目负责人:李友瑞

Carvacrol: antibacterial activity, bone repair, and prevention and treatment in oral diseases

Zhang Zihan, Wang Wenli, Li Jinnuo, Li Yourui   

  1. Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
  • Received:2021-09-18 Accepted:2021-10-25 Online:2022-09-18 Published:2022-03-09
  • Contact: Li Yourui, MD, Associate chief physician, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
  • About author:Zhang Zihan, Master candidate, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
  • Supported by:
    Shandong Provincial Medicine and Health Science and Technology Development Project, No. 2017WS753 (to LYR); Science and Technology Planning Project of Binzhou Medical University, No. BY2016KJ006 (to LYR)

摘要:

文题释义:
香芹酚:单萜类化合物,常见于牛至、百里香和其他植物中,是一种耐药性低、抗菌活性强并且有助于骨愈合的天然抗菌成分。香芹酚可加入生物膜、漱口水、水门汀等材料中应用于临床口腔常见疾病的治疗。
抗菌活性:指抗菌药抑制或杀灭病原菌微生物的能力。可用体外抑菌实验和体内实验治疗法测定。

背景:天然植物提取物香芹酚的抗菌性、低耐药性和低细胞毒性可代替抗生素,具有很好的前景。
目的:综述香芹酚的抗感染活性及其对口腔常见疾病防治的临床应用。
方法:利用计算机检索PubMed、中国知网数据库中相关文献,以“香芹酚,抗菌,口腔,成骨”为中文关键词,“carvacrol,antibacterial,oral,osteogenesis”为英文关键词进行检索,检索时限为2011年1月至2021年6月,通过阅读和分析对文献进行初步筛选,以排除重复文献和低相关性文献,最终纳入49篇文献进行结果分析。
结果与结论:实验证明香芹酚对龋病、口腔念珠菌病、牙周炎和种植体周围炎等多种口腔常见疾病的病原菌、细菌生物膜均有显著的抑菌性。香芹酚与抗生素联合使用产生协同作用,可增强疗效,降低耐药性。即使在高浓度下,香芹酚依然可以保持低细胞毒性,安全性良好。另外,香芹酚还可抑制破骨细胞分化,有助于修复骨损伤,减轻骨组织破坏,可应用于骨组织工程。基于以上生物特性,将其加入抗菌药、生物屏障膜、漱口水中可应用于口腔疾病的临床治疗。

https://orcid.org/0000-0002-4131-3172 (张子晗) 

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 挥发类酚, 天然植物精油, 香芹酚, 口腔, 抗菌, 病原菌, 凝胶, 成骨

Abstract: BACKGROUND: Carvacrol is a natural plant extract that acts as a substitute of antibiotics and has a good prospect because of its antibacterial activity, low drug resistance and low cytotoxicity.   
OBJECTIVE: To review the antibacterial activity and clinical applications of carvacrol in the prevention and treatment of common oral diseases.  
METHODS: PubMed and CNKI database were searched by computer using the keywords of “carvacrol, antibacterial, oral, osteogenesis” in English and Chinese, respectively. The retrieval period was from January 2011 to June 2021. Preliminary screening of literature was conducted through reading and analysis to exclude duplicate and low-correlation literature. Finally, 49 articles were included for result analysis.  
RESULTS AND CONCLUSION: Experimental results have shown that carvacrol exerts significant antibacterial effects on the pathogens and bacterial biofilms of various common oral diseases, such as dental caries, oral candidiasis, periodontitis and peri-implantitis. The combined use of carvacrol and antibiotics produces a synergistic effect, which can enhance curative effect and reduce drug resistance. Even at high concentrations, carvacrol can still maintain low cytotoxicity and good safety. In addition, carvacrol can inhibit osteoclast differentiation, help repair bone defects and reduce bone destruction, which can be used in bone tissue engineering. Considering the above biological characteristics, carvacrol can be added into antibacterial drugs, biological barrier films and mouthwashes, which can be used in the clinical treatment of oral diseases.  

Key words: volatile phenolics, natural plant essential oils, carvacrol, oral, antibacterial, pathogenic bacteria, gel, osteogenesis

中图分类号: