中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (15): 2394-2399.doi: 10.12307/2022.597

• 骨科植入物相关临床实践 Clinical practice of orthopedic implant • 上一篇    下一篇

中老年人体成分与骨密度的关系

袁嘉尧1,林燕平1,林贤灿1,黄佳纯2,陈桐莹1,林  适1,连晓航1,万  雷2,黄宏兴2   

  1. 1广州中医药大学,广东省广州市   510000;2广州中医药大学第三附属医院,广东省广州市   510000
  • 收稿日期:2021-06-16 修回日期:2021-06-17 接受日期:2021-07-26 出版日期:2022-05-28 发布日期:2022-01-06
  • 通讯作者: 黄宏兴,博士,教授,主任中医师,广州中医药大学第三附属医院,广东省广州市 510000
  • 作者简介:袁嘉尧,男,1995年生,广东省东莞市人,汉族,广州中医药大学在读硕士,主要从事中医药防治骨质疏松症方面的研究。
  • 基金资助:
    国家自然科学基金面上项目(81973886),项目负责人:黄宏兴;广州中医药大学“双一流”与高水平大学学科协同创新团队项目(2021XK21),项目负责人:黄宏兴;广州中医药大学学科研究重点项目(XK2019028),项目负责人:黄宏兴

Correlation between body composition and bone mineral density in middle-aged and elderly people

Yuan Jiayao1, Lin Yanping1, Lin Xiancan1, Huang Jiachun2, Chen Tongying1, Lin Shi1, Lian Xiaohang1, Wan Lei2, Huang Hongxing2   

  1. 1Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China; 2the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
  • Received:2021-06-16 Revised:2021-06-17 Accepted:2021-07-26 Online:2022-05-28 Published:2022-01-06
  • Contact: Huang Hongxing, MD, Professor, Chief physician, the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
  • About author:Yuan Jiayao, Master candidate, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
  • Supported by:
    the National Natural Science Foundation of China (General Project), No. 81973886 (to HHX); “Double First Class” and High-level University Discipline Collaborative Innovation Team Project of Guangzhou University of Chinese Medicine, No. 2021XK21 (to HHX); Subject Research Key Project of Guangzhou University of Chinese Medicine, No. XK2019028 (to HHX)

摘要:

文题释义:
体成分:指身体内各种成分的含量(如肌肉、骨骼、脂肪、水和矿物质等),其总质量就是体质量,能反映人体的体质状况、体型特征和身材大小。
骨密度:指单位体积 (体积密度) 或者是单位面积 (面积密度) 所含的骨量,目前公认的骨质疏松症诊断标准是基于双能X射线吸收法测量的骨密度值。

背景:骨质疏松症容易导致中老年人自理能力下降、死亡率和相关医疗费用增加,人体内主要体成分脂肪、肌肉和骨骼的关系并未阐明,因此需要研究它们的关系,并确定患者患骨质疏松症的潜在预测因子。
目的:测量中老年人体成分和骨密度相关指标,并分析之间的关系。
方法:纳入109例中老年人受试者,记录身高、体质量等信息,通过双能X射线骨密度仪测定骨密度及体成分。根据骨密度结果将受试者分为骨质疏松组及非骨质疏松组,分析两组基础资料、骨密度、各部位骨矿含量、肌肉质量和脂肪质量的分布及关系,卡方检验研究不同性别患骨质疏松症的比率,利用Pearson相关性分析得出各因素与骨密度的相关程度。
结果与结论:①女性更容易患骨质疏松症;②骨质疏松组年龄显著高于非骨质疏松组;③骨质疏松组体质量、体质量指数、骨密度、(整体、头部、主干、下肢)骨矿含量、(整体、头部、主干、下肢)肌肉质量、(整体、头部、上肢、下肢)脂肪质量显著低于非骨质疏松组,差异有显著性意义;④Pearson相关分析提示,中老年人整体骨密度与身高、体质量、(整体、头部、主干、上肢、下肢)骨矿含量、(整体、头部、主干、下肢)肌肉质量、头部脂肪质量呈显著正相关,与年龄呈显著负相关;⑤提示女性更容易患骨质疏松症,而且患有骨质疏松症的中老年人年龄更大,各部位骨矿含量、肌肉质量、脂肪质量均较非骨质疏松症人群有所降低;中老年人群骨密度与各部位骨矿含量、肌肉质量相关度较大;因此体成分可以作为评价骨骼健康状况的间接参考指标,各部位骨矿含量、肌肉质量和脂肪质量对整体骨密度具有一定的影响。

https://orcid.org/0000-0002-4557-525X (袁嘉尧);https://orcid.org/0000-0001-6211-9793 (黄宏兴)

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程

关键词: 骨质疏松症, 体成分, 骨密度, 肌肉质量, 脂肪质量

Abstract: BACKGROUND: Osteoporosis can easily lead to a decline in the self-care ability of middle-aged and elderly people, and an increase in mortality and related medical expenses. The relationship among the main body components of the human body (fat, muscle, and bone) has not been clarified. Therefore, it is necessary to study their relationship and identify potential predictors of osteoporosis in patients.  
OBJECTIVE: To investigate the correlation between body composition and bone mineral density of the middle-aged and elderly people.
METHODS:  A total of 109 middle-aged and elderly people were selected as subjects, and their heights, body mass and other information were recorded. The dual-energy X-ray bone densitometer was used to detect the bone mineral density and body composition. According to the results of body mineral density, the subjects were divided into an osteoporosis group and a non-osteoporosis group. The distribution and relationship of basic data, bone mineral density, bone mineral content, lean mass and fat mass of each part were analyzed between the two groups. Chi-square test was used to detect the ratio of osteoporosis in different sexes, and Pearson correlation analysis was used to obtain the correlation degree of each factor and bone mineral density.  
RESULTS AND CONCLUSION: Women were more likely to suffer from osteoporosis. The age of the osteoporosis group was significantly higher than that of the non-osteoporosis group. Body mass, body mass index, bone mineral density, bone mineral content (overall, head, trunk, lower limbs), lean mass (overall, head, trunk, lower limbs), and fat mass (overall, head, upper limbs, lower limbs) in the osteoporosis group were significantly lower than those in the non-osteoporosis group. Pearson correlation analysis indicated that the bone mineral density of middle-aged and elderly people was significantly positively correlated with height, body mass, bone mineral content (overall, head, trunk, upper limbs, lower limbs), lean mass (overall, head, trunk, lower limbs) and fat mass (head), and negatively correlated with age. Therefore, osteoporosis is more common in women, and the middle-aged and elderly people with osteoporosis are older. Their bone mineral content, lean mass and fat mass of each part are lower than those without osteoporosis. The bone mineral density of the middle-aged and elderly people is highly correlated with the bone mineral content and lean mass of each part. Therefore, body composition can be used as an indirect reference index to evaluate the bone health status. Bone mineral content, lean mass and fat mass of each part have certain influence on the bone mineral density.

Key words: osteoporosis, body composition, bone mineral density, lean mass, fat mass

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