中国组织工程研究

中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (6): 954-958.doi: 10.12307/2022.184

• 骨与关节图像与影像Bone and joint imaging • 上一篇    下一篇

基于薄层CT扫描参数建立呼和浩特地区8-16岁男性青少年颈椎骨龄的方程式

易新容1，贾富全1，何  鑫2，张少杰1，任小燕3，李志军1   

  1. 1内蒙古医科大学，内蒙古自治区呼和浩特市   010000；2内蒙古医科大学附属人民医院核医学科，内蒙古自治区呼和浩特市   010000；3内蒙古医科大学附属医院内分泌科，内蒙古自治区呼和浩特市   010000
  • 收稿日期:2021-04-08 修回日期:2021-04-19 接受日期:2021-05-21 出版日期:2022-02-28 发布日期:2021-12-08
  • 通讯作者: 李志军，硕士，教授，内蒙古医科大学，内蒙古自治区呼和浩特市 010000
  • 作者简介:易新容，女，1991年生，四川省万县人，汉族，内蒙古医科大学在读硕士，主要从事骨龄的研究。
  • 基金资助:
    国家自然科学基金(81860383)，项目负责人：李志军；国家自然科学基金(81660358)，项目负责人：张少杰；内蒙古自然科学基金资助项目(2019MS08017)，项目负责人：张少杰；内蒙古医科大学博士科研启动基金项目(YKD2018BSJJ009)，项目负责人：贾富全

Establishment of cervical bone age equation for male adolescents aged 8-16 years old in Hohhot based on thin-slice CT

Yi Xinrong1, Jia Fuquan1, He Xin2, Zhang Shaojie1, Ren Xiaoyan3, Li Zhijun1    

  1. 1Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China; 2Department of Nuclear Medicine, Affiliated People’s Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China; 3Department of Endocrinology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
  • Received:2021-04-08 Revised:2021-04-19 Accepted:2021-05-21 Online:2022-02-28 Published:2021-12-08
  • Contact: Li Zhijun, Master, Professor, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
  • About author:Yi Xinrong, Master candidate, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81860383 (to LZJ); National Natural Science Foundation of China, No. 81660358 (to ZSJ); Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2019MS08017 (to ZSJ); Doctoral Scientific Research Start Fund Project of Inner Mongolia Medical University, No. YKD2018BSJJ009 (to JFQ)

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摘要：

文题释义：
骨龄：是骨骼年龄的简称，正常人体骨骼发育过程中初级、次级骨化中心的出现时间、骨化速度、骨骺与干骺端闭合时间、顺序以及形态变化都具有一定的规律性，通过影像片观测这一变化规律并以“岁”或“月”来表示。
多元线性回归：在回归分析中，如果有2个或2个以上的自变量，就称为多元回归。由多个自变量的最优组合共同来预测或估计因变量，比只用一个自变量进行预测或估计更有效，更符合实际。

背景：目前国内骨龄评估方法以手腕骨最为经典，但该方法存在重复性差、易受评估者水平影响等不足，因此很难在多数地区开展。通过建立颈椎骨龄方程式，为该地区开展骨龄鉴定提供参考依据。
目的：探讨应用定量化的指标制定符合呼和浩特青少年男性的颈椎骨龄方程式，为骨龄鉴定等提供参考依据。
方法：选取8-16岁正常男性青少年颈椎151例薄层CT资料，随机分为2组，第1组111例作为骨龄预测方程的数据；第2组40例作为方程的检验数据。测量分析颈椎二维、三维参数。通过多元线性回归制定基于二维或二维联合三维参数的颈椎骨龄方程。采用Pearson相关性分析检验通过回归方程计算出的骨龄与生活年龄的相关性，比较引入三维参数前、后预测准确率。研究方案的实施符合《赫尔辛基宣言》和内蒙古医科大学对研究的相关伦理要求，受试者及监护人对检测及资料采集过程完全知情同意。
结果与结论：①基于二维参数和二维、三维联合建立的颈椎骨龄方程式分别为Y=4.454+1.443×D3+0.544×PH4 (D3为C3椎体下缘凹陷高度，PH4为C4椎体后缘高度)；Y=5.422+1.393×D3+0.413×AH3 (AH3为C3椎体前缘高度)；经相关性分析，2个方程计算出的骨龄与生活年龄均高度相关，r值分别为0.905，0.833(均P < 0.01)；②基于二维参数建立的骨龄方程式拟合优度和预测准确率均高于基于二维、三维联合参数建立的骨龄方程式；③结果说明，通过薄层CT的定量化指标发现，呼和浩特地区男性青少年颈椎二维参数C3椎体下缘凹陷高度和C4椎体后缘高度与骨龄密切相关。

https://orcid.org/0000-0003-2118-0656 (易新容) 

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 骨骼年龄, 生活年龄, 颈椎, 多元回归方程, 三维重建, 呼和浩特

Abstract: BACKGROUND: At present, the most classic domestic bone age assessment method is the wrist bone, but this method has disadvantages such as poor reproducibility and susceptibility to the level of the assessor, so it is difficult to carry out in most areas. Through the establishment of the cervical vertebra bone age equation, it provides a reference for the development of bone age identification in this area.  
OBJECTIVE: To explore the application of quantitative indicators to establish the cervical vertebra bone age equation for adolescent male in Hohhot and to provide references for skeletal age identification.
METHODS:  The thin-slice CT data of 151 normal male adolescents aged 8-16 years with cervical spine were selected and randomly divided into two groups. 111 cases in the first group were used as the data of the bone age prediction equation; 40 cases in the second group were used as the test data of the equation. The two-dimensional and three-dimensional parameters of the cervical spine were measured and analyzed. Multiple linear regression was used to make the bone age equation based on two-dimensional morphological parameters or two-dimensional and three-dimensional morphological parameters. Pearson correlation analysis was used to test the correlation between the bone age and the age of life calculated by the regression equation to compare the accuracy of the prediction before and after the introduction of three-dimensional parameters. The protocols were in accordance with the Declaration of Helsinki and the relevant ethical requirements of the Inner Mongolia Medical University. The subjects and guardians had fully informed consent to the testing and data collection.  
RESULTS AND CONCLUSION: (1) The cervical spine age equations based on two-dimensional parameters and two-dimensional and three-dimensional joints were Y=4.454+1.443×D3+0.544×PH4 (D3 is the height of the depression of the lower edge of the C3 vertebral body; PH4 is the height of the posterior edge of the C4 vertebral body); Y=5.422+1.393×D3+0.413×AH3 (AH3 is the height of the anterior edge of the C3 vertebral body). After correlation analysis, the bone age calculated by the two equations was highly correlated with the age of life, and the r values were 0.905 and 0.833, respectively (all P < 0.01). (2) The goodness of fit and prediction accuracy of the bone age equation based on two-dimensional parameters were higher than the bone age equation based on two-dimensional and three-dimensional joint parameters. (3) Results confirmed that through the quantitative index of slice CT, it was found that the height of the lower edge of C3 vertebra and the height of the posterior edge of C4 vertebra were closely related to the bone age of male adolescents in Hohhot area. 

Key words: bone age, living age, cervical spine, multiple regression equation, three-dimensional reconstruction, Hohhot

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