Effects of different concentrations of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction

doi:10.3969/j.issn.2095-4344.2013.50.008

Abstract

Abstract:

BACKGROUND: Platelet-rich plasma contains growth factors that can promote tendon-bone healing, thereby reducing occurrence of bone tunnel enlargement after anterior cruciate ligament reconstruction; different concentrations of platelet-rich plasma have certain influence on bone tunnel enlargement, but it is not clear which concentration is optimal.
OBJECTIVE: To study the effect of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction.
METHODS: Bilateral anterior cruciate ligament reconstruction was conducted in 20 New Zealand white rabbits using Martinek et al’s method. Tendon graft was pretreated with 10 mg platelet-rich plasma gel on one side as an observation group. Graft on the contralateral limb was pretreated with 5 mg platelet-rich plasma gel as control group. At 12 weeks after surgery, radiological observation and measure of the width of bone tunnel were conducted. Tunnel enlargement rate was calculated.
RESULTS AND CONCLUSION: At 8 and 12 weeks after anterior cruciate ligament reconstruction, the width of tunnel enlargement was less in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P < 0.05). Bone density of tendon-bone interface was larger in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P < 0.05). These results indicated that platelet-rich plasma promoted in bone density of tendon-bone interface after rabbit anterior cruciate ligament reconstruction, effectively prevented enlargement of bone tunnel. Moreover, 10 mg platelet-rich plasma is perfect.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: platelet-rich plasma, anterior cruciate ligament, tenotomy

CLC Number:

R318

Li Hong-qiu, A Liang, Zhao Zhong-hai, Dong Li-yang. Effects of different concentrations of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.50.008.

Figures/Tables 3

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