Preventive analgesia of Celebrex for patients receiving total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2013.48.002

Abstract

Abstract:

BACKGROUND: The preemptive analgesia is still a controversial issue. Existing studies have not paid much attention to effects of preoperative factors on the hypersensitivity of peripheral and central mechanisms. Visual analog scale scores cannot subjectively and repeatedly reveal patient’s pain.
OBJECTIVE: To investigate the validity of the preventive analgesia effect of Celebrex in patients with total knee arthroplasty.
METHODS: Patients with osteoarthritis of the knee who received total knee arthroplasty were accessed by Pittsburgh sleep quality index, self-rating depression scale and self-rating anxiety scale. In all, thirty patients were enrolled in the study. They were randomized into Celebrex group and vitamin C group, and each group had 15 patients. The patients in the Celebrex group and vitamin C group took 200 mg Celebrex and vitamin C, respectively, twice a day from day 2 to day 4. Both of their knees were evaluated by resting visual analogue scale and moving visual analogue scale in the evening of day 1 before treatment and day 3 after treatment. Meanwhile, the pain threshold and pain tolerance were accessed by a pain-threshold machine.
RESULTS AND CONCLUSION: No statistical significance of the changes of resting and moving visual analogue scale scores was found in both knees in the Celebrex group (P > 0.05). The pain threshold of both knees were significantly increased (P < 0.05), and the severe knee, which had less visual analogue scale scores than the minor one, turned out to increase more obviously than the minor knee (P > 0.05). There were no significant changes in the pain tolerance in both knees (P > 0.05). The changing values of resting or moving visual analogue scale were not significantly correlated with the pain threshold and pain tolerance (P > 0.05). There were no significant changes in visual analogue scale scores, pain threshold and pain tolerance in both knees of the vitamin C group (P > 0.05). Celebrex could increase the pain threshold of patients receiving total knee arthroplasty, especially the severe knee, which indicates that the Celebrex is good for the preventive analgesia. Comparatively speaking, the pain threshold might be more sensitive than visual analogue scale in revealing the change of pain after analgesia. There is no significant correlation between visual analogue scale score and the hypersensitivity of pain.

Key words: pain, cerebrex, knee joint, arthroplasty, replacement, knee, electric stimulation

CLC Number:

R318

Lin Zi-hong, Wang Hai-xing, Chen Gui-hao, Wang Liang-ze, Shen Zi-wei, Ma Yuan-chen, Liao Jun-xing, Zheng Qiu-jian. Preventive analgesia of Celebrex for patients receiving total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(48): 8307-8312.

Figures/Tables 4

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