Abstract:

BACKGROUND: At present, cryopreserved method is used to reduce immunological rejection after cartilage allograft transplantation, but allograft source, cryopreservation method, and frozen storage conditions still need in-depth studies.
OBJECTIVE: To retrospectively analyze the action mechanism related to immunological rejection reaction following transplantation of cryopreserved cartilage allograft, and to compare the characteristics of different preservation methods.
METHODS: The search by the first author was performed to retrieve PubMed and Wanfang databases for articles about immunological rejection following transplantation of cryopreserved cartilage allograft and cryopreservation effects on cartilage transplantation published 1990 to 2008.
RESULTS AND CONCLUSION: Cartilage allograft transplantation is better than other treatments for patients with articular cartilage defects. The cryopreservation method maintains the properties and biological activity of cartilage tissues, and based on this method, we can choose date for joint reconstruction and have plenty of time to complete the detection of a number of indicators so as to prevent the spread of bacteria, viruses and infectious diseases carried by the donor, and to reduce the antigenicity of cartilage tissue, with great clinical value. However, in all aspects of cryopreservation, such as, the application of cryoprotectant, cooling and rewarming speed, there are still many problems. And after cartilage transplantation, there is occurrence of cartilage resorption, degeneration and so on. With the development of frozen biology and revealing of frozen injury mechanism, these problems will be met, cartilage cryopreservation technology will be further improved.