Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (50): 9333-.doi: 10.3969/j.issn.1673-8225.2010.50.006

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Expression of mammalian target of rapamycin/P70S6K in pathologic scars
 

Yuan De-pin 1,2, Niu Fu-you1, Chen Min-jing1, Wang Xi-mei 1, Li Yong-tao 1,2

 
  

  1. 1 Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; 2 Open Laboratory of Key Discipline of Clinical Medical Sciences, Institutions of Henan Province High Learning, Zhengzhou 450052, Henan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • Contact: Niu Fu-you, Professor, Chief physician, Master’s supervisor, Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China niufuyou@zzu.deu.cn
  • About author:Yuan De-pin★, Studying for master’s degree, Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; Open Laboratory of Key Discipline of Clinical Medical Sciences, Institutions of Henan Province High Learning, Zhengzhou 450052, Henan Province, China yuandepin@126.com Chen Min-jing, Professor, Chief physician, Master’s supervisor, Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China chenmj67@yahoo.com.cn Yuan De-pin and Chen Min-jing contributed equally to this paper

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Abstract:

BACKGROUND: In recent years, related research has shown that mammalian target of rapamycin/P70S6K (mTOR/P70S6K) signaling pathway has a role in tumor formation. Pathologic scar, especially the keloid scar, with the nature of some tumors, therefore mTOR/P70S6K signal pathway may be of great significance in the formation of pathological scars.
OBJECTIVE: To investigate the role of mTOR/P70S6K signalling pathway in pathologic scars.
METHODS: SP immunohistochemical method was used to detect the expressions of phosphated mTOR (p-mTOR) and phosphated PTOS6K (p-P70S6K) p-mTOR and p-P70S6K in keloid, hypertrophic scar, non-pathologic scar and normal skin tissues. All the scar tissues were taken from the patients who were diagnosed clearly by the clinic, and they were confirmed by pathology.
RESULTS AND CONCLUSION: The positive rates of p-mTOR and p-P70S6K in keloid and hypertrophic scars were higher compared with the two control groups (P < 0.05). There was a highly positive correlation between p-mTOR and p-P70S6K expression in pathologic scars (r=0.482, P < 0.05). The activation of mTOR/P70S6K signalling pathway might be involved in the formation of pathologic scar, and the factors of it may cooperate to promote the progress of pathologic scars.

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