中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (50): 7571-7578.doi: 10.3969/j.issn.2095-4344.2016.50.018

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

从进化论角度探讨干细胞分化及其干细胞巢分布规律

张建新   

  1. 江苏润华冷冻食品有限公司,江苏省兴化市  225700
  • 修回日期:2016-08-25 出版日期:2016-12-02 发布日期:2016-12-02
  • 作者简介:张建新,男,1971年生,江苏省兴化市人,汉族,1990年南通纺织工业学校毕业,主要从事粒子物理学和生物遗传学的理论研究。

Evolutionary mechanisms for stem cell differentiation and stem cell niche distribution

Zhang Jian-xin   

  1. Jiangsu Runhua Frozen Food Co., Ltd., Xinghua 225700, Jiangsu Province, China
  • Revised:2016-08-25 Online:2016-12-02 Published:2016-12-02
  • About author:Zhang Jian-xin, Jiangsu Runhua Frozen Food Co., Ltd., Xinghua 225700, Jiangsu Province, China

摘要:

文章快速阅读:

 

文题释义:
经络系统:《
黄帝内经》称之为“决死生”、“处百病”的“灵枢”,即是灵验的“中枢”与“本源”。印度瑜珈理论(如Kundalini Yoga的气脉学说)称之为“Kundalini”(生命力)的“源泉”。 李时珍的《奇经八脉考》曰:“内景隧道,唯返观者能照察之”。古今中外的返观者发现,人体不同组织中的腧穴均为圆形结构,彼此离散地串珠式分布。作者认为,只有不同种类的成体干细胞等所处的干细胞巢,才能具有如此高度相同相似的细胞团结构。
板块:借用地质学的“板块”概念,首先是反映经络系统的高级结构单位(一个个类似于伞状分布的腧穴群落)具有不可分割的整体性特征,其次是强调板块之间必须满足一定的内在条件才能相互衔接或者彼此相邻,否则同样会出现“板块碰撞”现象,后者将深度影响所属细胞组织的结构功能,尤其是有的板块碰撞会导致赘生物的发生。

 

摘要
背景:
造血干细胞、神经干细胞和诱导多能干细胞等越来越多的干细胞被发现,目前尚未出现关于干细胞分类和干细胞分化的统一理论;造血干细胞巢、肠上皮干细胞巢和毛囊干细胞巢等越来越多的干细胞巢被发现,目前尚未出现公认的干细胞巢形成和分布的统一理论;20年过去了,“不同种类干细胞巢的有序分布构成中医经络系统”的观点未能得到干细胞研究者(特别是中国的)重视。
目的:从进化论角度探讨干细胞分化及其干细胞巢分布规律。
方法:参阅《黄帝内经》等中医经典理论著作和人体解剖学著作,再一次从中医经络学说方向阐明干细胞巢在组织中的分布规律。参阅现代动物分类学著作,根据生物重演律、物种进化树和中医经络学说等探讨干细胞分化的规律。

结果与结论:高等动物胚胎发育的三胚层阶段以极其简洁的方式直接跨越其无脊椎动物祖先的演化史,生物重演律描述的基本对象首先应该是两条干细胞分化链 和经络系统中干细胞巢分布的演变。现今公认的物种进化树将后口动物的祖先设想为某种原始两侧对称动物是完全错误的,从干细胞分化角度来看违背了达尔文进化论原理,物种进化树不可能分叉形成顶部互不相干的两大分支——原口动物和后口动物,蟑螂、矛尾鱼和银杏等不可能是活化石,物种的起源是多源的,物种的进化是多层次波浪式向前推进。

 

 

关键词: 干细胞, 分化, 腧穴, 干细胞巢分布, 经络, 干细胞分化, 等级, 板块, 整体性, 四色定理, ;诱导多能干细胞, 癌症干细胞

Abstract:

BACKGROUND: More and more stem cells such as hematopoietic stem cells, neural stem cells and induced pluripotent stem cells have been discovered, but there is no unified theory on stem cell classification and stem cell differentiation. Similarly, more and more stem cell niches, such as niches of hematopoietic stem cells, intestinal epithelial stem cells and hair follicle stem cells, have been found, and there is still no unified theory on the formation and distribution of stem cell niches. In the past 20 years, the viewpoint that “the orderly distribution of different types of stem cell niches constitutes the meridian system of Chinese medicine” has not been taken seriously, especially in China.
OBJECTIVE: To explore the evolutionary mechanisms for stem cell differentiation and stem cell niche distribution.
METHODS: With the reference of the Inner Canon of Yellow Emperor and literature on human anatomy, we further explained the distribution rule of stem cell niches in various tissues from the perspective of meridian theory. We explored the law of stem cell differentiation based on the biogenetic law, species evolutionary tree and the theory of meridians of Chinese medicine.
RESULTS AND CONCLUSION: The embryonic development with the formation of three germ layers in higher animals directly transcends the evolutionary history of their invertebrate ancestors in an extremely simple way. The basic objects described in the biogenetic law should first be two stem cell differentiation chains   and    as well as the evolution of the distribution of stem cells in the meridian system. The presently accepted species evolutionary tree assumes that the ancestor of the deuterostomia is a primitive bilaterally symmetric animal, which is completely wrong. It violates the Darwinian principle of evolution from the viewpoint of stem cell differentiation, and the evolutionary tree cannot fork to form two branches, protostomia and deuterostomia, that are unrelated on the their origins. Cockroaches, spearfish and ginkgo cannot be living fossils. The origin of the species is multi-sources, and the species evolution is ongoing in a multi-level wavy manner.

 

 

Key words: Stem Cells, Meridians, Cell Differentiation, Medicine, Chinese Traditional, Tissue Engineering

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