中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (2): 310-316.doi: 10.3969/j.issn.2095-4344.0651

• 生物材料综述 biomaterial review • 上一篇    下一篇

自组装短肽水凝胶:止血效应与机制研究进展

卫 巍,刘燕飞,张 玲,熊 娜   

  1. 遵义医学院附属医院贵州省细胞工程重点实验室,贵州省遵义市 563003
  • 收稿日期:2018-08-09 出版日期:2019-01-18 发布日期:2019-01-18
  • 通讯作者: 刘燕飞,博士,副教授,硕士生导师,遵义医学院附属医院贵州省细胞工程重点实验室,贵州省遵义市 563003
  • 作者简介:卫巍,男,1992年生,湖北省十堰市人,汉族,遵义医学院在读硕士,主要从事自组装短肽设计、特性及组织工程方向的研究。
  • 基金资助:

    贵州省联合资金资助项目(黔科合J字LKZ[2013]01号,项目负责人:刘燕飞);贵州省教育厅自然科学研究项目(黔教合KY字[2015]418)

Self-assembling peptide hydrogel: hemostatic effect and mechanism

Wei Wei, Liu Yanfei, Zhang Ling, Xiong Na   

  1. Key Laboratory of Cell Engineering in Guizhou Province, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Received:2018-08-09 Online:2019-01-18 Published:2019-01-18
  • Contact: Liu Yanfei, MD, Associate professor, Master’s supervisor, Key Laboratory of Cell Engineering in Guizhou Province, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Pr
  • About author:Wei Wei, Master candidate, Key Laboratory of Cell Engineering in Guizhou Province, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Supported by:

    the Key Project of Guizhou Province Science and Technology Department, No. LKZ[2013]01 (to LYF); and the Natural Science Research Project of Education Department of Guizhou Province, No. KY[2015]418

摘要:

文章快速阅读:

 

文题释义:
自组装:是指基本结构单元(分子,纳米材料,微米或更大尺度的物质)自发形成有序结构的一种技术。在自组装的过程中,基本结构单元在基于非共价键的相互作用下自发组织或聚集为一个稳定、具有一定规则几何外观的结构。
水凝胶:凡是水溶性或亲水性的高分子,通过一定的化学交联或物理交联,都可形成水凝胶。自组装短肽材料能够依靠物理性的非共价键作用介导,自组装形成纳米纤维水凝胶,可为细胞提供与天然细胞外基质类似的三维微环境,影响细胞的生长、迁移、分化等生物学行为。
 
 
背景:自组装短肽水凝胶作为一种新型的生物材料,被广泛应用于组织工程、药物释放、止血和抗菌剂等方面。
目的:总结近年来自组装短肽水凝胶材料在不同出血模型中的止血效应和机制研究进展。
方法:以“自组装短肽,水凝胶,止血,外伤;self-assembling peptide,hydrogel,hemostasis,trauma”为检索词,检索PubMed、CNKI、万方数据库2000至2018年发表的相关文献。

结果与结论:自组装短肽材料具有可编程、黏弹性好、生物相容性高和低免疫原性等特性;自组装短肽在生理条件下可形成纳米纤维水凝胶,表现出良好的生物相容性,在不同外科手术伤口中,水凝胶可形成物理屏障,发挥止血效果,而不与凝血级联相互作用或受凝血级联影响,快速有效地控制出血而不伤害周围组织或细胞。合理利用短肽的抗菌和药物缓释特性,在保证快速止血效应的同时,改善伤口微环境,联合生物活性分子共同促进伤口愈合,是现阶段自组装短肽材料的重点研究方向之一。ORCID: 0000-0002-4152-9432(卫巍)

关键词: 自组装短肽, 水凝胶, 止血, 生物相容性, 生物材料, 综述

Abstract:

BACKGROUND: As a new type of biomaterial, self-assembling peptide hydrogel is widely used in tissue engineering, drug release, hemostasis and antibacterial agents.

OBJECTIVE: To summarize the hemostatic effect and mechanism of self-assembling peptide hydrogel materials in different bleeding models.
METHODS: Using “self-assembling peptide, hydrogel, hemostasis, trauma” as the key words in Chinese and English, respectively, we retrieved the related literatures published from 2000 to 2018 in PubMed, CNKI, WanFang databases.

RESULTS AND CONCLUSION: Self-assembling peptide materials are characterized as programmability, good viscoelasticity, high biocompatibility and low immunogenicity. The short peptides can self-assemble into nanofiber hydrogels and exhibit good biocompatibility. In different surgical wounds, hydrogels can form physical barriers to exert hemostasis without interacting with the clotting cascade or being coagulated, which can quickly and effectively control bleeding without harm to surrounding tissues or cells. Reasonable use of short peptides that have antibacterial and drug sustained-release properties can ensure rapid hemostatic effect, and meanwhile improve wound microenvironment. Self-assembling peptide hydrogel combined with bioactive molecules to promote wound healing is one of the key research directions of self-assembling short peptide materials at this stage.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Hydrogel, Hemostasis, Biocompatible Materials, Tissue Engineering

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